Cortical atrophy in dementia with Lewy Bodies follows a hippocampal-sparing signature pattern

Takeaway

  • Patients with dementia with Lewy bodies (DLB) have widespread cortical atrophy that follows a signature pattern consisting of a hippocampal-sparing type but have less overall atrophy compared with Alzheimer’s disease (AD).

Why this matters

  • Less structural atrophy suggests DLB is due to functional brain changes which are potentially reversible and amenable to drug therapy.