Cortical GABAA receptor concentrations, pain levels and function in fibromyalgia

Takeaway

  • Cortical GABAA receptor concentrations are upregulated in fibromyalgia (FM) and associated with increased pain levels and higher impact on function.

Why this matters

    The upregulation of GABAA receptors in FM supports the hypothesis that there is an imbalance between excitatory and inhibitory neurotransmission in chronic pain conditions.