Cortical gyrification and white matter microstructure abnormalities in Parkinson’s disease motor phenotypes


  • Compared with healthy controls, people with the akinetic-rigid (AR-) Parkinson’s disease (PD) subtype but not tremor-dominant (TD-) PD subtype had decreases in local gyrification index (LGI) and fractional anisotropy (FA).

Why this matters

  • Clinical studies indicate that PD subtypes have varying underlying patterns of brain alterations; this study supports that cortical gyrification changes are motor-phenotype specific and may be related to microstructural white matter abnormalities