Cortical thickness linked to changes in major histocompatibility complex region in schizophrenia


  • The relationship between cortical thickness and single nucleotide polymorphisms (SNPs) in the major histocompatibility complex (MHC) region supports the pivotal role of the immune system in the pathology of schizophrenia.

Why this matters

  • By demonstrating that SNPs in the MHC region may alter brain anatomy, the study provides in vivo evidence to support the role of the immune system in the pathogenesis of schizophrenia, advancing our understanding of the trajectory of the disease.