Creutzfeldt-Jakob disease and the propagation of prion protein in the vagus nerve

Takeaway

  • Prion protein depositions in the vagus nerve in people with sporadic versus genetic Creutzfeldt-Jakob disease (CJD) are morphologically distinct.

Why this matters

  • Morphologically distinct depositions of prion protein in vagus nerve suggests a non-uniform propagation and has implications for other neurodegenerative diseases which share prion-like pathogenic mechanisms, including alpha-synuclein in Parkinson’s disease.