Cumulative genetic risk, APOEε4 and dementia status in a multiethnic cohort


  • APOEε4 and cumulative genetic risk for Alzheimer’s disease (AD) are both independent predictors of dementia in individuals with European ancestry.

Why this matters

  • AD is implicated in 70% of dementia cases, and genome-wide association studies have identified numerous related single nucleotide polymorphisms (SNPs); thus, based on this, AD cumulative risk can be summarized via polygenic scores (PGS). However, PGS, independent of APOEε4, have not been tested in multiethnic cohorts.

  • The status of APOEε4 and cumulative genetic risk as independent dementia predictors highlight the utility of polygenic scores in dementia, and the importance of further multiethnic study into this condition to support management, therapy development and therefore, more favorable outcomes for patients.