Cyclic-AMP response element binding protein and sustained wakefulness: an animal model


  • The cyclic-AMP response element binding protein (CREB) is required in neurons within the forebrain, but not the locus coeruleus (LC), to encourage and stabilize wakefulness.

Why this matters

  • Pathways and cell-firing patterns within the LC and other brain regions have known involvement in wakefulness promotion; however, little is known about intracellular processes underlying sleep/wake regulation, and while studies show an associated role in this process for CREB, the precise neural location of this is uncertain.

  • A deeper understanding of processes and brain regions underlying sleep/wake regulation may be beneficial in developing targeted therapies to treat specific sleep disorders, potentially reducing comorbidities, and improving outcomes and quality of life for patients.