Defining animal models of Alzheimer’s Disease


  • Mouse models of Alzheimer’s Disease (AD) are significantly different: ‘Line 1’ (L1) mice more accurately represent AD whereas ‘Line 66’ (L66) mice display a frontotemporal lobar degeneration (FTLD) phenotype.

Why this matters

  • An in-depth understanding of acetylcholine activity and cholinergic pathways is key to understanding the pathology of AD.

  • Better animal models of AD are needed as current models do not address the link between inflammation due to activated microglia and astrocytes, and cholinergic forebrain degeneration.