Defining prognostic biomarkers in amyotrophic lateral sclerosis


  • High levels of low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (ApoB) are associated with longer overall survival in amyotrophic lateral sclerosis (ALS).

Why this matters

  • Dyslipidemia is a common feature in ALS, and previous studies have suggested a causal link between dyslipidemia and ALS.

  • The role of lipids as prognostic biomarkers in ALS has been investigated with conflicting results and the specific roles of ApoB and apolipoprotein A1 (apoA1) have not been studied.