Defining the imaging features of progressive supranuclear palsy


  • Patients with progressive supranuclear palsy (PSP) display similar magnetic resonance imaging (MRI) features as those with idiopathic normal pressure hydrocephalus (iNPH).

Why this matters

  • Studies suggest that some cases with an ante-mortem diagnosis of iNPH had postmortem diagnoses of neurodegenerative disorders, including PSP.

  • It is possible that iNPH and PSP share similar MRI features, such as appearance of disproportionately enlarged subarachnoid space hydrocephalus (DESH), thus making differential diagnosis difficult.