Degenerative processes in the retina are seen in chronic inflammatory demyelinating polyneuropathy

Takeaway

  • There is subtle retinal neurodegeneration in people with chronic inflammatory demyelinating polyneuropathy, which suggests visual pathway involvement.

Why this matters

  • Chronic inflammatory demyelinating polyneuropathy primarily affects the peripheral nervous system, although recent evidence indicates that inflammatory central nervous system demyelination may be implicated.

  • In this unique study, structural retinal changes were identified using spectral domain optical coherence tomography which uses near-infrared light to generate cross-sectional and 3-dimensional images of the retina as part of the central nervous system.

  • The findings highlight potentially important structural changes which could be functionally relevant and represent future therapeutic targets.