There is subtle retinal neurodegeneration in people with chronic inflammatory demyelinating polyneuropathy, which suggests visual pathway involvement.
Why this matters
Chronic inflammatory demyelinating polyneuropathy primarily affects the peripheral nervous system, although recent evidence indicates that inflammatory central nervous system demyelination may be implicated.
In this unique study, structural retinal changes were identified using spectral domain optical coherence tomography which uses near-infrared light to generate cross-sectional and 3-dimensional images of the retina as part of the central nervous system.
The findings highlight potentially important structural changes which could be functionally relevant and represent future therapeutic targets.