Delayed alcohol-induced headache


  • The clinical characteristics of delayed alcohol-induced headache (DAIH) include a typically bilateral presentation with moderate intensity, frontal predominance and a pressing quality.

Why this matters

  • Studies defining the DAIH phenotype and its underlying mechanisms are scarce, although a role for antidiuretic hormone inhibition and related neurotransmitter activity is postulated, causing potential mimicry of low cerebrospinal fluid (CSF) pressure headache or migraine.

  • Hangovers and associated DAIH are severe enough to impact daily function, but little is known about management strategies other than alcohol cessation. Deeper insight into the phenotype and its processes may support future development of these strategies and may also be beneficial for migraine and low CSF pressure headaches due to observed similarities.