Deletion versus depletion : mitochondrial DNA and sporadic inclusion body myositis

Takeaway

  • Individuals with sporadic inclusion body myositis (sIBM) have lower mitochondrial DNA (mtDNA) copy number than healthy controls and those with necrotizing myopathy.

Why this matters ?

  • Deletions of mtDNA are associated with sIBM, but depletions of mtDNA may be more relevant to the pathogenesis of the disease.