Dementia risk and variability in systolic blood pressure postural changes


  • Systolic orthostatic hypotension and variability in visit-to-visit systolic blood pressure (SPB) are associated with increased dementia risk in the aging population.

Why this matters

  • Orthostatic hypotension (OHYPO) and higher blood pressure (BP) variability is associated with cardiovascular events and all-cause mortality in the elderly, but their association with cognitive outcomes is unclear.

  • These findings could impact the use and development of interventions to control orthostatic SBP and reduce fluctuations, possibly reducing incidence or risk of dementia.