Takeaway
Systolic orthostatic hypotension and variability in visit-to-visit systolic blood pressure (SPB) are associated with increased dementia risk in the aging population.
Why this matters
Orthostatic hypotension (OHYPO) and higher blood pressure (BP) variability is associated with cardiovascular events and all-cause mortality in the elderly, but their association with cognitive outcomes is unclear.
These findings could impact the use and development of interventions to control orthostatic SBP and reduce fluctuations, possibly reducing incidence or risk of dementia.