Dendritic pathology and synaptic reorganization in brain tissue from epilepsy patients

Takeaway

  • Fine morphological aspects of neurons and dendritic spines are normal in epileptogenic neocortex, with the exception of type II focal cortical dysplastic (FCD) lesions.

Why this matters

  • Changes in dendritic morphology and spine loss, particularly in hippocampal neurons are reported in animal models of epilepsy and human brain tissue; however, whether these changes result from causative epilepsy factors or seizure recurrence is unclear.

    Further study of underlying mechanisms resulting in FCD lesions is required as this may potentially support development of targeted treatment agents for focal epilepsies, particularly in patients with chronic illness, leading to improved outcomes and quality of life.