Depression may have causal role in AD, genetic study suggests

Researchers have presented new insights into possible molecular mechanisms underlying the association between depression and the risk of Alzheimer’s disease (AD).

Many prospective studies have indicated that depression increases the risk of developing AD, and recent research has identified a genetic correlation between them. At the AAIC conference, Dr Nadia Harerimana from Emory University School of Medicine, in Atlanta, Georgia, USA, reported the findings of a new comprehensive analysis.

This was based on data from the largest published genome-wide association studies (GWAS) of depression and of AD, and on transcriptome and proteome profiles (N=580 and N=468, respectively) derived from postmortem brains of individuals in three prospective studies of aging and dementia.