Ganglion cell-inner plexiform layer (GC-IPL) intereye retinal thickness difference (IETD) may be an alternative biomarker for detecting asymptomatic optic nerve lesions.
Why this matters
During the clinically isolated syndrome (CIS) stage, symptomatic and asymptomatic optic nerve lesions are common. Despite their frequencies, the optic nerve is not part of the diagnostic criteria for multiple sclerosis (MS). Previous studies have suggested an improvement in diagnosing MS when the optic nerve is included in the criteria. The results of this study may provide an alternative biomarker to magnetic resonance imaging (MRI) for detecting asymptomatic optic nerve lesions in individuals with CIS.