Detecting tau deposition in people with amyotrophic lateral sclerosis/parkinsonism dementia complex

Takeaway

  • Using the radioligand [11C]PBB3 for positron emission tomography (PET) scans on people from the Kii Peninsula of Japan with amyotrophic lateral sclerosis/parkinsonism dementia complex (ALS/PDC) revealed tau pathologies indicative of the clinical phenotypes of ALS/PDC.

Why this matters

  • Due to the prevalence of ALS/PDC in people from the Kii Peninsula of Japan, imaging tau pathology related to the disease in these people can provide answers regarding its pathogenesis.