Detection of alpha-synuclein by real-time quaking-induced conversion assay

Takeaway

  • Real-time quaking-induced conversion (RT-QuIC) assay to detect alpha-synuclein (α-syn) aggregates in cerebrospinal fluid (CSF) may be a reliable diagnostic tool to help clinicians differentiate α-synucleinopathies from other forms of parkinsonism.

Why this matters

  • The clinical picture regarding parkinsonism can be unclear and a reliable means to differentiate α-synucleinopathies from other forms of parkinsonism could aid treatment decisions.