Determinants associated with seizure-free outcome in posterior disconnection surgery for epilepsy


  • Posterior disconnection (PD) of the temporal, parietal, and occipital lobes is more likely to yield a seizure-free outcome (SFO) when pathology is clearly localized to the posterior quadrant (PQ) and PD is complete.

Why this matters

  • PD is technically demanding, and evidence has not indicated a clear advantage over resection for refractory posterior quadrant epilepsy (PQE).

  • Identification of determinants associated with SFO may help clinicians identify individuals who are most likely to benefit from PD.