Diagnostic criteria for dementia with Lewy bodies

Takeaway

  • The operationalized criteria identified for mild cognitive impairment with Lewy bodies (MCI-LB) is sufficient to apply and test immediately; however, operationalization of specific criteria for delirium-onset and psychiatric-onset is not yet justified.

Why this matters

    In prodromal dementia with Lewy bodies (DLB), clinical manifestations such as cognitive deficits and sleep disorders can occur up to 15 years before disease onset. Identifying precise early diagnostic criteria for DLB is essential to distinguish this from similar clinical manifestations in diseases like Parkinson’s disease and Alzheimer’s disease and to enable early intervention before clinical symptoms become debilitating.