Diagnostic value of cerebrospinal fluid microRNA in people with multiple sclerosis


  • People with multiple sclerosis (MS) are more likely to have elevated cerebrospinal fluid (CSF) levels of microRNA (miR)-181c and miR-633 compared to people with other neurological diseases (OND), indicating its value as a diagnostic tool.

Why this matters

  • Early diagnosis of MS can lead to improvements in clinical outcomes; however, there is no clear test for unspecific symptoms, or a test to predict disease course.

  • There is potential for the use of miRNAs from CSF as biomarkers for MS, particularly miR-181c and miR-633.