Differential default mode network – how is it affected in people at risk of Alzheimer’s ?

Takeaway

  • Individuals with subjective memory complaints (SMC) display default mode network (DMN) resting state functional connectivity (rsFC) changes in the frontal and posterior regions of the brain as well as the hippocampus; presence of APOE ε4 slows the increase of FC in frontal lobes during aging.

Why this matters ?

  • Understanding the impact of functional brain dynamics and genetics on risk of Alzheimer’s disease in those at risk of disease can help develop clinically relevant biomarkers.