Differentiating myelitis in two neuro-ophthalmologic disorders in Chinese Han patients


  • Myelitis is less commonly observed in myelin oligodendrocyte glycoprotein-antibody (MOG-ab)-associated disease (MOGAD), and demonstrates distinct features compared to those of aquaporin 4-antibody (AQP4-ab)-positive neuromyelitis optica spectrum disorder (NMOSD).

Why this matters

  • Myelitis is a major clinical component of MOGAD and AQP4-ab-positive NMOSD, often making it difficult to distinguish between the two, and since it can lead to severe disability, accurate diagnosis is vital for early and effective treatment.

  • A novel prediction model to distinguish between MOGAD and AQP4-ab-positive NMOSD-associated myelitis may constitute both an alternative diagnostic tool to antibody testing and a surveillance tool to monitor fluctuating titer levels of MOG-ab during remission or therapy, potentially aiding earlier intervention and enhancing patient quality of life.