Differentiating vulnerability from disease manifestation in Huntington’s disease using neuroimaging

Takeaway

  • GM volume, global brain atrophy, and perivascular space burden could all be used as indicators of disease progression in HD.

Why this matters

  • There is a need to identify reliable markers of disease progression in HD, across a range of ethnic groups.

  • This study is the first to explore the role and prevalence of perivascular spaces (PVS) in HD, and highlights this as a potential neuroimaging marker for disease progression.