Diffusion basis spectrum imaging elucidates pathophysiology of post-hemorrhagic hydrocephalus


  • Diffusion basis spectrum imaging (DBSI) provides an insight into the neuropathology of neonatal post-hemorrhagic hydrocephalus (PHH) and may open the door to new treatment strategies.

Why this matters

  • Around 20% of premature infants develop intraventricular hemorrhage (IVH), which can lead to post-hydrocephalus ventricular dilation and then PHH.

  • Infants with PHH can suffer cognitive deficits and cerebral palsy; and PHH is a leading cause of epilepsy and hearing, visual, and speech impairment.

  • To date, diffusion tensor imaging (DTI) has been used to characterize the white matter damage seen in infants with PHH, but this technique has its limitations in terms of sensitivity and specificity. DBSI is now being investigated to improve understanding of PHH-related injury.