Takeaway
Evaluation of white matter integrity in complex regional pain syndrome (CRPS) may help to better understand abnormalities in pain-related perception.
Why this matters ?
CRPS is a chronic neuropathic pain disorder typically characterized by a combination of sensory, autonomic, and motor disturbances together with severe and debilitating pain that is often disproportionate to the inciting event.
Previous research has suggested that structural and functional abnormalities in regions of the prefrontal cortex (PFC) are closely related to pain catastrophizing and have been found in patients with CRPS.