Diffusion tensor imaging may elucidate the correlation between white matter integrity and CRPS


  • Evaluation of white matter integrity in complex regional pain syndrome (CRPS) may help to better understand abnormalities in pain-related perception.

Why this matters ?

  • CRPS is a chronic neuropathic pain disorder typically characterized by a combination of sensory, autonomic, and motor disturbances together with severe and debilitating pain that is often disproportionate to the inciting event.

  • Previous research has suggested that structural and functional abnormalities in regions of the prefrontal cortex (PFC) are closely related to pain catastrophizing and have been found in patients with CRPS.