Diminished hippocampal tail volume and executive dysfunction occurs at the prediabetes stage


  • The left posterior hippocampus, particularly the left hippocampal tail, is affected earlier in hyperglycemia‐associated hippocampal atrophy, even in prediabetic individuals, and is associated with executive dysfunction.

Why this matters

  • This is the first in vivo study to investigate the effects of blood glucose level on hippocampal subfield volume in the early stage of diabetes.

  • Left hippocampal tail volume may be an early marker of diabetes‐related brain damage, which could assist clinicians in identifying adults in the prediabetes stage at risk of developing cognitive impairment.