Disease severity and body mass index in children with Charcot-Marie-Tooth disease

Takeaway

  • Children with Charcot-Marie-Tooth disease (CMT) who are severely underweight or obese experience greater disability than those who were in healthy weight, underweight or overweight body mass index (BMI) categories.

Why this matters

  • CMT is the most common inherited neuromuscular disorder, characterized by distal to proximal reduction in muscle bulk, muscle weakness, gait difficulties, hand and foot deformity, sensory loss, and areflexia.

  • BMI has been shown to influence function in children with neuromuscular disorders and may affect disability in CMT, but little is known about the effect of BMI on CMT severity.