Disruptions in network function underlie the link between neuroinflammation and cognitive decline

Takeaway

  • Neuroinflammation in Alzheimer’s disease is associated with reorganization of large-scale brain networks, with the strength of the association related to the degree of cognitive impairment.

Why this matters

  • Neuroinflammation has long been linked to progression of Alzheimer’s disease. Understanding that this is mediated by effects on brain network function may help to identify immunotherapeutic strategies to slow or prevent cognitive decline.