Takeaway
Patients with non-canonical isocitrate dehydrogenase (IDH)-mutant gliomas have distinct radiological and histological features compared with the more common canonical IDH1 p.R132H mutant gliomas.
Why this matters
Even though the WHO glioma classification (2016) suggests that the type of IDH mutation has no impact on diagnosis, approximately 10% of gliomas have non-canonical IDH mutations in the IDH1 or IDH2 genes.
Limited studies have described patient characteristics of non-canonical IDH mutant gliomas.