Distinct differences of non-canonical IDH mutant gliomas


  • Patients with non-canonical isocitrate dehydrogenase (IDH)-mutant gliomas have distinct radiological and histological features compared with the more common canonical IDH1 p.R132H mutant gliomas.

Why this matters

  • Even though the WHO glioma classification (2016) suggests that the type of IDH mutation has no impact on diagnosis, approximately 10% of gliomas have non-canonical IDH mutations in the IDH1 or IDH2 genes.

  • Limited studies have described patient characteristics of non-canonical IDH mutant gliomas.