Distinct distributions of white matter hyperintensities associated with specific risk factors

Takeaway

  • Visceral adiposity increases the probability of white matter hyperintensities in deeper white matter (dWMH), and the effect appears to be partially mediated by the inflammatory cytokine interleukin-6 (IL-6).

Why this matters

    Identification of distinct spatial distributions of white matter hyperintensities (WMH) associated with specific risk factors may improve understanding of underlying pathologic mechanisms.