Distinct sources of disease-specific antibodies in cerebrospinal fluid in neuromyelitis optica spectrum disorder


  • In people with neuromyelitis optica spectrum disorder, intrathecal production of anti-myelin oligodendrocyte glycoprotein antibodies is more common than anti-aquaporin-4 antibodies.

Why this matters

    The observed differences in proportions of intrathecal origin between the antibodies in the cerebrospinal fluid suggest that different properties of B-cell trafficking, and antibody production exist between the two types of disease. These important findings highlight the need for differential diagnosis and management of the two antibody-specific types of neuromyelitis optica spectrum disorder.