Distribution of iron in multiple sclerosis immunopatterns

Takeaway

  • In the two most common immunopatterns in multiple sclerosis (MS), immunopattern II and III lesions, there is heterogeneous iron content and distribution.

Why this matters

    The differential distribution of iron supports the concept of pathogenic heterogeneity in MS. In the future, iron-sensitive imaging techniques may be able to detect immunopatterns in those with MS, without an invasive biopsy, to better tailor treatment strategies.