Divergence in astrocytic environment amongst sporadic Creutzfeldt-Jakob disease patients

Takeaway

  • A1 astrocyte markers C3 and GBP2 are significantly elevated in sporadic Creutzfeldt-Jakob disease (sCJD) and stratify to molecular subtype parameters of disease.

Why this matters

    Phenotyping of disease may lead to the identification of optimal strategies to target A1 astrocytes and the specific patient populations that would benefit most from the targeted therapies across a range of broadly related neurodegenerative conditions, including sCJD.