DNA methylation and ischemic stroke

Takeaway

  • CASZ1 is hypomethylated in Chinese patients with hypertensive ischemic stroke (IS), suggesting that DNA methylations may be a risk factor for hypertension and ischemic stroke.

Why this matters

  • Genetic and epigenetic factors are widely implicated in IS and hypertension, an important IS causative factor; however, while GWAS studies have identified several linked loci for blood pressure and IS, underlying functional factors are not fully understood.

  • Identification of high-risk genes and interactions for IS and hypertension has important implications for modifiable risk factor management such as diet, given that IS is the second leading cause of death worldwide.