Do botulinum toxin injections alter cortical excitability?


  • Botulinum toxin type A injections in early Parkinson’s disease (PD) resulted in significant reductions in tremor severity that were associated with improvements in sensorimotor integration deficits and intracortical inhibition.

Why this matters

  • Botulinum toxin therapy in PD can result in long-lasting reductions in tremor frequency and severity.

  • These findings are the first to suggest that tremor severity reduction by botulinum toxin is associated with alterations within the cerebellothalamocortical circuit.