Do quantitative magnetic resonance imaging features have discriminative power in patients with multiple sclerosis?

Takeaway

  • Individual lesion myelin water fraction (MWF) and volume could differentiate patients with multiple sclerosis (MS) into two distinct subgroups that significantly correlated with clinical disability.

Why this matters

  • MS is a highly heterogenous disease, and prognostication of individual disease course remains a challenge.

  • These findings provide evidence of patient-specific pathophysiological processes and may be used to define disease trajectories and guide future therapeutic approaches.