Does α4-integrin absence in B cells affect disease in an autoimmune encephalomyelitis disease model?


  • These preclinical data indicate that α4-integrin deficiency in B cells does not affect disease in a T-cell–mediated autoimmune encephalomyelitis (EAE) disease model.

Why this matters

  • The results suggest that the beneficial effects of B-cell-depleting therapies used in multiple sclerosis (MS) are mediated through their effects on peripheral B cells, and suppression of B cell migration into the central nervous system (CNS) is not likely to underlie the efficacy of anti-α4-integrin therapy in MS.