Does diabetes influence Alzheimer’s disease biomarker expression?


  • Diabetes was significantly associated with increased cerebrospinal fluid (CSF) total tau (t-tau) levels in patients with apolipoprotein E (APOE) ε4+ Alzheimer’s disease (AD).

Why this matters

  • Diabetes and the APOE ε4 allele are both known risk factors for AD development.

  • The co-occurrence of these factors in individuals may confer greater AD risk – particularly if they interact to accelerate cognitive decline – and suggests that these patients should be more thoroughly monitored.