Dorsal Root Ganglia Volume as a Diagnostic Biomarker for Neurofibromatosis Type 2

Takeaway

  • Dorsal root ganglia (DRG) hypertrophy and peripheral nerve lesions are evidenced early in the development of neurofibromatosis type 2 (NF2), and peripheral nervous system (PNS) alterations in children with NF2 are similar to those of adults.

Why this matters

  • The cause of neuropathic symptoms of NF2 is poorly understood, but recent studies have implicated noncompressive microlesions along peripheral nerves and severe DRG hypertrophy as potential markers.

  • Finding an NF2 diagnostic marker that can be applied in the clinic will aid with early diagnosis or diagnosis in difficult cases.