Early Onset Alzheimer’s Disease Associated With Elevated LDL Cholesterol and APOB Coding Variants


  • Elevated LDL cholesterol (LDL-C) levels were associated with higher probability of having early onset Alzheimer’s disease (EOAD) and in those with EOAD rare coding variants in APOB (which code for the major protein of LDL-C).

Why this matters

  • Much is known about the genetic basis of late-onset Alzheimer’s Disease (AD). However, early onset Alzheimer’s disease (EOAD), a rare form of AD, is not well understood.

  • This study sheds light on the role of LDL-C in EOAD pathogenesis and suggests a direct link of APOB variants and risk of AD, which may be of use in the future identification of at-risk individuals.