Early remedial hypothermia in people undergoing surgical removal of acute subdural hematomas does not improve outcomes


  • Rapid induction of hypothermia prior to craniotomy for traumatic acute subdural hematomas does not improve global neurological outcome at 6 months.

Why this matters

  • Hypothermia can have neuroprotective properties in ischemia-reperfusion injuries. This multicenter, randomized clinical trial was terminated early because there was no obvious benefit from hypothermia seen at a 6-month interim futility analysis. Technology for therapeutic hypothermia has advanced substantially over the past few decades and is now easier to implement with reliable temperature control. However, these findings indicate that further studies are needed to determine any potential therapeutic benefits in people with acute subdural hematomas.