Early tau-related pathology precedes memory impairment in a genetic mouse model

Takeaway

  • Early tauopathy affects brain connectivity showing that dysregulation of neuronal network activity precedes cognitive impairment in prodromal dementia.

Why this matters

    These novel findings suggest that circuitry features may underlie early pathological mechanisms in Alzheimer’s disease which appear before cognitive impairment. This could lead to an early biomarker of tauopathy in prodromal Alzheimer’s disease and eventually provide novel therapeutic targets.