Echogenicity alterations of brainstem raphe: a marker for depression among migraineurs?


  • Individuals with migraine without aura and hypoechogenicity of the brainstem raphe (BR), as detected by transcranial sonography (TCS), are more likely to have concomitant depression.

Why this matters

  • BR hypoechogenicity is commonly observed in people with major depression; however, its presence and importance among individuals with migraine and depression is undetermined.