Effect of chronic demyelination on neuroaxonal loss in MS patients

Takeaway

  • Chronic demyelination is associated with progressive axonal loss in human multiple sclerosis patients.

Why this matters

  • Axonal loss, brought about by inflammatory demyelination, is now accepted as the major key cause of irreversible neurologic disability in MS.

  • Although widely demonstrated in numerous in vitro and animal models, the clinical significance of chronic demyelination as a precursor of axonal damage in humans is yet to be established.