Effect of thalamic centromedian stimulation in individuals with epilepsy


  • Physiological arousal in the cortical regions of the brain may have a role in the therapeutic benefits of intralaminar thalamic deep brain stimulation in individuals with epilepsy.

Why this matters

  • Previous studies have suggested that in disorders such as epilepsy, decreased activity in the subcortical arousal circuitry, including the intralaminar thalamus, may be pivotal in causing depressed cortical arousal and impaired attention.

  • This may be overcome by the use of deep brain stimulation of the intralaminar central lateral thalamus to reduce seizures and improve arousal and cognition, but the mechanism behind this is not well understood.