Effects of high-intensity aerobic exercise on features of brain MRI in multiple sclerosis

Takeaway

  • In people with multiple sclerosis (MS), high-intensity progressive aerobic exercise (PAE) for 24 weeks did not result in disease-modifying effects on MRI but the exercise regimen did lead to cardiorespiratory fitness improvements and a lower relapse rate compared with the waitlist group.

Why this matters

    Prior work has described the potential for exercise to positively impact the symptoms of MS and brain MRI features, however, no long-term study investigating PAE and disease progression via MRI has been performed in people with MS.