Efficacy of 5-hydroxytryptophan on depressive symptoms in Parkinson’s disease


  • 5-Hydroxytryptophan (5-HT) significantly improves symptoms of depression in people with Parkinson’s disease (PD).

Why this matters

    Around one-third of people with PD experience symptoms of depression, yet there has been limited research on the use of 5-HT in this population. The findings suggest that 5-HTP could be used to counteract levodopa-induced serotonergic dysfunction in people with PD.