Quantitative imaging fat fraction of elbow flexor muscles in males with Duchenne muscular dystrophy predicts loss of hand-to-mouth movement that is not connected to age.
Why this matters
Although quantitative magnetic resonance imaging fat fraction of the vastus lateralis muscle is known to predict ambulatory loss in Duchenne muscular dystrophy, its predictive value must be additive to age. This important study shows that elbow flexor fat fraction can predict loss of hand-to-mouth movement independent of age. Quantitative magnetic resonance imaging fat fraction could be used as a biomarker in this disease and may be useful as a surrogate endpoint in clinical trials.